Peptidomimetics in organic and medicinal chemistry

by Trabocchi, Andrea

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Title Statements

Full title :Peptidomimetics in organic and medicinal chemistry / Dr. Andrea Trabocchi and Professor Antonio Guarna.

Edition Statements

Publication Date:2014.

Publication Statements

Publisher(s):John Wiley et Sons, Inc
Place of Publication:Chichester, West Sussex, UK
Language:eng
Publication Date:2014.

Notes

"A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands. Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery"-

"Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature"-

The Physical Object

Description:1 online resource

Edition Identifiers

ISBN:9781118683149, 1118683145, 9781118683842, 1118683846, 9781119950608, 9781118683033, 111868303X, 1119950600, 9781306546980, 1306546982
DOI:10.1002/9781118683033
oclc:ocn992847767
Dewey Decimal:615.1/9