Personalized epigenetics

by Tollefsbol, Trygve O.

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Title Statements

Full title :Personalized epigenetics / Trygve O. Tollefsbol ; designer, Mark Rogers ; contributors, Vanessa Aguiar-Pulido [and forty five others].

Summary

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

Edition Statements

Publication Date:©2015

Publication Statements

Publisher(s):Academic Press
Place of Publication:Amsterdam, Netherlands
Language:eng
Publication Date:©2015

The Physical Object

Description:1 online resource (611 pages) : : illustrations, tables.

Edition Identifiers

ISBN:9780128004364, 0128004363, 0124201350, 9780124201354
oclc:ocn909895146
LC Classification:QH450
Dewey Decimal:572.865

Front Cover -- PERSONALIZED EPIGENETICS -- Copyright -- Contents -- Contributors -- Preface -- SECTION I -- OVERVIEW -- Chapter 1 -- Epigenetics of Personalized Medicine -- 1. INTRODUCTION -- 2. EPIGENETIC VARIATIONS AMONG INDIVIDUALS -- 3. BIOINFORMATICS OF PERSONALIZED EPIGENETICS -- 4. DIAGNOSTIC AND PROGNOSTIC EPIGENETIC APPROACHES TO PERSONALIZED MEDICINE -- 5. ENVIRONMENTAL PERSONALIZED EPIGENETICS -- 6. PHARMACOLOGY AND DRUG DEVELOPMENT OF PERSONALIZED EPIGENETICS -- 7. PERSONALIZED EPIGENETICS OF DISORDERS AND DISEASE MANAGEMENT -- 8. CHALLENGES AND FUTURE DIRECTIONS -- 9. CONCLUSION -- References -- SECTION II -- EPIGENETICVARIATIONS AMONGINDIVIDUALS -- Chapter 2 -- Interindividual Variability of DNA Methylation -- 1. INTRODUCTION -- 2. BIOCHEMICAL PATHWAYS REGULATING DNA METHYLATION -- 3. CHALLENGES IN STUDYING DNA METHYLATION -- 4. CLASSIFICATION OF EPIGENOTYPES -- 5. EARLY EVIDENCE OF INTERINDIVIDUAL VARIATION IN DNA METHYLATION FROM DNA METHYLATION MUTANTS -- 6. STUDIES OF NATURAL VARIATION IN DNA METHYLATION-MODEL SYSTEMS -- 7. STUDIES OF NATURAL VARIATION IN DNA METHYLATION-HUMANS -- 8. TWIN STUDIES -- 9. METHYLATION QUANTITATIVE TRAIT LOCI AND EPIGENETIC QUANTITATI…