Phenotypic Variation: Exploration and Functional Genomics
by Smith, Moyra
During the past two decades international collaborative studies have yielded extensive information on genome sequences, genome architecture and their variations. The challenge we now face is to understand how these variations impact structure and function of organelles, physiological systems and phenotype. The goal of this book is to present steps in the pathways of exploration to connect genotype to phenotype and to consider how alterations in genomes impact disease. In this book the author re…
Read More ↓Title Statements
- Full title :Phenotypic Variation : Exploration and Functional Genomics.
Summary
During the past two decades international collaborative studies have yielded extensive information on genome sequences, genome architecture and their variations. The challenge we now face is to understand how these variations impact structure and function of organelles, physiological systems and phenotype. The goal of this book is to present steps in the pathways of exploration to connect genotype to phenotype and to consider how alterations in genomes impact disease. In this book the author reviews published research in functional genomics carried out primarily since 2006 that sheds light on.
Read More ↓Edition Statements
- Publication Date:2011.
Publication Statements
- Publisher(s):Oxford University Press
- Place of Publication:New York
- Language:eng
- Publication Date:2011.
The Physical Object
- Description:1 online resource (253 pages)
Edition Identifiers
- ISBN:0195379632, 9780195379631
- oclc:ocn990468619
- LC Classification:QH438.5 .S65 2010
- Dewey Decimal:576.5/3
Table of Contents
Cover; Contents; 1. Phenotype and Functional Genomics: Introduction; 2. Evolution; 3. Genomic Architecture and Copy Number Changes; 4. Linkage, Association, and Linkage Disequilibrium; 5. Regulation of Transcription, Splicing and Translation: Impact of Perturbation on Phenotype; 6. Mitochondria: Genome, Functions, and Phenotype; 7. Quality Surveillance; 8. Neurodevelopment and Functional Genomics; 9. Neurobehavioral Disorders; 10. Molecular Analyses of Malformation Syndromes; 11. Multiple Pathways including Environmental Factors that Lead to a Specific Phenotype with Later Onset; 12. Epilogue.
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