Platelets

"Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and therapy to increase platelet numbers and/or function. Since the publication of the Third Edition of Platelets, there has been a rapid expansion of knowledge in both basic biology of platelets and the clinical approach to platelet-related diseases. This Fourth Edition of Platelets draws all this information into a single, comprehensive and authoritative resource."--Website publisher

Includes index.

Front Cover; Platelets; Copyright; Contents; Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; The Role of Platelets in Human Hemostasis, Platelet Transfusion, and Bleeding Time; Immune Thrombocytopenia; Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; Platelet Physiology, Assays of Platelet ``Adhesiveness, ́́ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Antag ... ; Aspirin, Arachidonic Acid, Prostaglandins, Eicosanoids, Nitric Oxide, Endothelial Ecto-ADPase (CD39), Angiogenesis, Micropa ...

A Comparison of Human Platelets and Limulus AmebocytesThe Evolution of Hemostasis and Blood Coagulation; Megakaryocytes and Mammals; Marine Mammals; Order Monotremata; Order Marsupialia; Platelet Levels; A Comparison of Nonplacental and Placental Mammals; Conclusions; References; Chapter 2: Megakaryocyte Development and Platelet Formation; Introduction; Megakaryocyte Development; The Hematopoietic Program; Committed Megakaryocyte Progenitor Cells; Immediate Megakaryocyte Precursors; Endomitosis and Polyploid Formation; Megakaryocyte Cytoplasmic Maturation; Invaginated Membrane System

Dense Tubular Syst…