Protein Folding in Silico

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Title Statements

Full title :Protein Folding in Silico.

Summary

Protein folding is a process by which a protein structure assumes its functional shape of conformation, and has been the subject of research since the publication of the first software tool for protein structure prediction. Protein folding in silico approaches this issue by introducing an ab initio model that attempts to simulate as far as possible the folding process as it takes place in vivo, and attempts to construct a mechanistic model on the basis of the predictions made. The opening chapters discuss the early stage intermediate and late stage intermediate models, followed by a discussion of structural information that affects the interpretation of the folding process. The second half of the book covers a variety of topics including ligand binding site recognition, the "fuzzy oil drop" model and its use in simulation of the polypeptide chain, and misfolded proteins. The book ends with an overview of a number of other ab initio methods for protein structure predictions and some concluding remarks. Discusses a range of ab initio models for protein structure prediction Introduces a unique model based on experimental observations Describes various methods for the quantitative assessment of the presented models from the viewpoint of information theory.

Edition Statements

Publication Date:2012.

Publication Statements

Publisher(s):Elsevier Science
Language:eng
Publication Date:2012.

The Physical Object

Description:1 online resource.

Edition Identifiers

ISBN:9781908818256, 1908818255
oclc:ocn969066843
LC Classification:QP551
Dewey Decimal:572/.633

Subjects

biochemistry computer simulation mathematical models Modèles mathématiques Models, Theoretical Protein Folding Protein folding -- Simulation methods Protéines -- Repliement Proteinfaltung Simulation Simulation par ordinateur