Protein-ligand interactions: methods and applications
by Daviter, Tina Williams, Mark A.
Proteins are the cell's workers, their messengers and overseers. In these roles, proteins specifically bind small molecules, nucleic acid and other protein partners. Cellular systems are closely regulated and biologically significant changes in populations of particular protein complexes correspond to very small variations of their thermodynamics or kinetics of reaction. Interfering with the interactions of proteins is the dominant strategy in the development of new pharmaceuticals. Protein Lig…
Read More ↓Title Statements
- Full title :Protein-ligand interactions : methods and applications / edited by Mark A. Williams, Tina Daviter.
Summary
Proteins are the cell's workers, their messengers and overseers. In these roles, proteins specifically bind small molecules, nucleic acid and other protein partners. Cellular systems are closely regulated and biologically significant changes in populations of particular protein complexes correspond to very small variations of their thermodynamics or kinetics of reaction. Interfering with the interactions of proteins is the dominant strategy in the development of new pharmaceuticals. Protein Ligand Interactions: Methods and Applications, Second Edition provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. From the initial discovery of natural substrates or potential drug leads, to the detailed quantitative understanding of the mechanism of interaction, all stages of the research process are covered with a focus on those techniques that are, or are anticipated to become, widely accessible and performable with mainstream commercial instrumentation. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Second Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions - whether they are beginning graduate students or experts in allied areas of molecular cell biology, microbiology, pharmacology, medicinal chemistry or structural biology.
Read More ↓Edition Statements
- Publication Date:©2013.
- Edition:2nd ed
Publication Statements
- Publisher(s):Humana Press
- Place of Publication:New York
- Language:eng
- Publication Date:©2013.
The Physical Object
- Description:1 online resource (x, 530 pages) : : illustrations
Edition Identifiers
- ISBN:9781627033985, 162703398X, 1627033971, 9781627033978
- DOI:10.1007/978-1-62703-398-5
- oclc:ocn847736186
- LC Classification:QP551
- Dewey Decimal:572/.6
Subjects
Writers
More from this Series
No reviews yet. Be the first to rate this work.
Related Works
more →
Biochemistry
Biochemistry
Modulation by covalent modification
Adhesion protein protocols
Self-organization in nonequilibrium systems: from dissipative structures to order th…
Nicolis, G.
Self-organization in nonequilibrium systems: from dissipative structures to order th…
Nicolis, G.
Schaum's outline of theory and problems of biochemistry
Quantitative methods in proteomics
Bioactive surfaces
Files & Downloads
-
Protein-Ligand Interactions: Methods and Applicat…
PDF · 8.6 MB · updated -
Protein-Ligand Interactions: Methods and Applicat…
PDF · 9.2 MB · updated
Rate & Review