Proteostasis and proteolysis

Proteostasis and proteolysis

by Chondrogianni, Niki

Type Book
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Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. Essential aspects of cell function are proeostasic and relevant for diseases such a cancer, obesity, and aging. Various pharmacological interventions can mitigate the impact of proteostatic breakdown. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system : the ubiquitin-proteasome system and …

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Title Statements

  • Full title :Proteostasis and proteolysis / edited by Niki Chondrogianni, Elah Pick, Anna Gioran.

Summary

Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. Essential aspects of cell function are proeostasic and relevant for diseases such a cancer, obesity, and aging. Various pharmacological interventions can mitigate the impact of proteostatic breakdown. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system : the ubiquitin-proteasome system and autophagy. These systems and their regulation are affected by endogenous stress and environmental stimuli. Deregulation in proteolysis results in proteostasis failure : protein misfolding and accumulation of damaged and oxidized proteins resulting in neurodegenerative diseases such Alzheimer's, parkinson's, and Huntington's.

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Edition Statements

  • Publication Date:copyright 2022

Publication Statements

  • Publisher(s):CRC Press
  • Place of Publication:Boca Raton [etc.]
  • Language:eng
  • Publication Date:copyright 2022

The Physical Object

  • Description:1 vol. (XII-260 p.) : : ill. ; : 26 cm.

Edition Identifiers

  • ISBN:9780367499327 (rel), 0367499320 (rel)
  • oclc:on1305389157

Subjects

Homéostasie protéique Oxydoréduction Proteolyse

Writers

Chondrogianni, Niki Gioran, Anna Pick, Elah

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