Psychostimulants

by Koob, George F.

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Title Statements

Full title :Psychostimulants / George F. Koob, Michael A. Arends, Mandy L. McCracken, Michel Le Moal.

Summary

Psychostimulant drugs, such as cocaine and amphetamines, of the indirect sympathomimetic class have a long history as tonics and other preparations to allay fatigue and sustain performance. These drugs also have a long history of abuse and dependence. Abuse potential varies with the availability of the drug both environmentally and physiologically, with intravenous and smoked forms of both cocaine and amphetamines producing much more severe substance use disorder. Cocaine and amphetamines have a characteristic abuse cycle that involves binge administration, withdrawal dysphoria, paranoia, and psychosis-like symptoms as the cycle continues or intensifies. Significant advances have been made in our understanding of the mechanisms of action of psychomotor stimulant drugs at the behavioral, neuropharmacological, cellular, and molecular levels that can be heuristically framed in the three-stage cycle of addiction: binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation. Eventually, three corresponding domains and neurocircuits coalesced around these three stages: binge/intoxication (incentive salience/pathological habits domain, basal ganglia neurocircuits), withdrawal/negative affect (negative affect domain, extended amygdala), and preoccupation/anticipation (executive function, prefrontal cortex). Thus, the new revised book, Neurobiology of Addiction, is now organized along the three stage/three domain construct while retaining synthesis at the circuit, cellular, and molecular levels of analysis.

Edition Statements

Publication Date:©2020

Publication Statements

Publisher(s):Academic Press, an imprint of Elsevier
Place of Publication:London, United Kingdom
Language:eng
Publication Date:©2020

The Physical Object

Description:1 online resource (viii, 253 pages) : : illustrations (some color)

Edition Identifiers

ISBN:9780128169919, 0128169915
oclc:on1153892733
LC Classification:RM315
Dewey Decimal:615.7/88

Definitions -- History of psychostimulant use -- Physiological effects -- Behavioral effects -- Pharmacokinetics -- Behavioral mechanism of action -- Medical use, abuse, and addiction -- Neurobiological effects -- Overall summary.