Sample preparation in LC-MS bioanalysis

by Fu, Yunlin Jian, Wenying Li, Wenkui

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Title Statements

Full title :Sample preparation in LC-MS bioanalysis / edited by Wenkui Li, Wenying Jian, and Yunlin Fu.

Edition Statements

Publication Date:©2019

Publication Statements

Publisher(s):John Wiley & Sons, Inc
Place of Publication:Hoboken, NJ
Language:eng
Publication Date:©2019

The Physical Object

Description:1 online resource

Edition Identifiers

ISBN:9781119274322, 111927432X, 9781119274308, 1119274303, 9781119274315, 1119274311
oclc:on1074297180
LC Classification:QD79.C454
Dewey Decimal:543/.84

Intro; Title Page; Copyright Page; Contents; List of Contributors; Preface; List of Abbreviations; Part I Current Sample Preparation Techniques in LC-MS Bioanalysis; Chapter 1 Basic Sample Preparation Techniques in LC-MS Bioanalysis: Protein Precipitation, Liquid-Liquid Extraction, and Solid-Phase Extraction; 1.1 Introduction; 1.2 Physicochemical Properties of Drugs and Their Metabolites; 1.2.1 Hydrophilicity vs. Lipophilicity of Analyte(s); 1.2.2 Protolytic Properties of Analyte(s); 1.3 Pre-analytical Variables of Analyte(s) of Interest in Biological Matrix; 1.3.1 Stability

1.3.2 Nonspecific Binding1.3.3 Protein Binding; 1.3.4 Blood-to-plasma Ratio and Red Blood Cell Partition; 1.4 Most Commonly Used Sample Preparation Methods in LC-MS Bioanalysis; 1.4.1 Protein Precipitation (PPT); 1.4.1.1 Water-miscible Organic Solvents; 1.4.1.2 Acids; 1.4.2 Liquid-Liquid Extraction (LLE); 1.4.2.1 Mechanism of LLE and Extraction Recovery; 1.4.2.2 Solvent in LLE; 1.4.2.3 General Procedures in LLE; 1.4.2.4 Application of LLE in LC-MS Bioanalysis; 1.4.2.5 Other Formats of LLE; 1.4.3 Solid-phase Extraction (SPE); 1.4.3.1 SPE Stationary Phases (Sorbents)

1.4.3.2 Common SPE Platforms in LC-MS Bioan…

Subjects

bioengineering Biotechnologie Biotechnology Chromatographie en phase liquide Chromatography, Liquid liquid chromatography mass spectrometry Science -- Chemistry Spectrométrie de masse