Structural aspects of protein synthesis: Anders Liljas, Måns Ehrenberg

This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases. Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation. There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system. Anders Liljas (Lund University, Sweden), Måns Ehrenberg (Uppsala University, Sweden). Publishers note.

Prevised edition 2004.

The Basics of Translation -- Historical Milestones -- Methods of Studying Structure -- The Message -- mRNA -- The Adaptor -- tRNA -- The Workbench -- Ribosomes -- The Structure of the Ribosome -- Ribosomal Sites and Ribosomal States -- The Catalysts -- Translation Factors -- Inhibitors of Protein Synthesis -- Antibiotics, Resistance -- The Process -- Translation -- Protein Processing, Folding and Targeting -- Evolution of the Translation Apparatus -- Appendix I. List of Ribosomal Proteins Classified on the Basis of Sequence Similarities -- Appendi II. The Domain Arrangement, Fold, Tails, Loops, Hinges, Location and Interactions of Ribosomal Proteins. Data on 30S Subunits from T. Thermophilus (Tt) by Carter et al. (2000); Brodersen et al. (2002) and Schlüntzen et al. (2000); on 50S Subunits from H. marismortui (Hm) by Ban et al. (2000) and Klein et al. (2004); on 50S subunits from D. radiodurans (Dr) by Harms et al. (2001); on E. coli 70S (Ec) (Schuwirth et al ., 2005); on T. thermophilus (T) 70S Ribosomes by Selmer et al . (2006) and Jenner et al. (2010).