Structure-based drug design

Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors...presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1...focuses on structure-based design strategies for uncovering receptor antagonists...demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment...reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators...describes the influence of structure-based methods in designing capsid-binding inhibitors...and much more. Structure-Based Drug Design is an essential resource for pharmaceutical scientists and pharmacologists; organic, medicinal, clinical, and analytical chemists and biochemists; molecular and cell biologists; drug-development personnel; biotechnologists; and upper-level undergraduate and graduate students in these disciplines.

1. AIDS. Inhibitors of HIV-1 protease / Krzysztof Appelt -- Structural studies of HIV-1 reverse transcriptase and implications for drug design / Jianping Ding, et al -- Retroviral integrase: structure as a foundation for drug design / Alison B. Hickman, Fred Dyda. 2. Arthritis and inflammation. Bradykinin receptor antagonists / Donald J. Kyle. 3. Cancer. Design of purine nucleoside phosphorylase inhibitors / Y. Sudhakara Babu, et al -- Structural implications in the design of matrix-metalloprotienase inhibitors / John C. Spurlino -- Structure-function relationships in hydroxysteroid dehydrogenases / Igor Tsigelny, Michael E. Baker -- Design of ATP competitive specific inhibitors of protein kinases using template modeling / Janusz M. Sowadski, et al. 4. Diabetes mellitus. Structural studies of aldose reductase inhibition / David K. Wilson, J. Mark Petrash, Florante A. Quiocho.

5. Heart diseases. Structure-based design of thrombin inhibitors / Patricia C. Weber, Michael Czarniecki -- Design of antithrombotic agents directed at factor Xa / William C. Ripka -- Polypeptide modulators of sodium channel function as a basis for the development of novel cardiac stimulants / Raymond S. Nor…