Structure-Based Drug Design

Cover -- Half Title -- Title Page -- Copyright Page -- Table of Contents -- Preface -- Contributors -- AIDS -- 1. Inhibitors of HIV-1 Protease -- 2. Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design -- 3. Retroviral Integrase: Structure as a Foundation for Drug Design -- ARTHRITIS AND INFLAMMATION -- 4. Bradykinin Receptor Antagonists -- CANCER -- 5. Design of Purine Nucleoside Phosphorylase Inhibitors -- 6. Structural Implications in the Design of Matrix-Metalloproteinase Inhibitors -- 7. Structure-Function Relationships in Hydroxysteroid Dehydrogenases -- 8. Design of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling -- DIABETES MELLITUS -- 9. Structural Studies of Aldose Reductase Inhibition -- HEART DISEASES -- 10. Structure-Based Design of Thrombin Inhibitors -- 11. Design of Antithrombotic Agents Directed at Factor Xa -- 12. Polypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants -- 13. Rational Design of Renin Inhibitors -- PARKINSON'S DISEASE -- 14. Structural Aspects in the Inhibitor Design of Catechol O-Methyltransferase -- SLEEPING SICKNESS -- 15. Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes -- IMMUNE DISEASES AND CYTOKINES -- 16. Progress in the Design of Immunomodulators Based on the Structure of Interleukin-1 -- 17. Structure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design -- ANTIVIRALS -- 18. The Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase -- 19. Rhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design -- NOVEL METHODOLOGIES

20. The Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery -- 21. Structure-Based Combinatorial Ligand Design -- 22. Peptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design -- Index