The Link Between Inflammation and Cancer: Wounds that do not heal

by Dalgleish, Angus G.

Type Book

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Title Statements

Full title :The Link Between Inflammation and Cancer : Wounds that do not heal / edited by Angus G. Dalgleish, Burkhard Haefner

Summary

The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book.

Edition Statements

Publication Date:2006

Publication Statements

Publisher(s):Springer Science+Business Media, Inc
Place of Publication:Boston, MA
Language:eng
Publication Date:2006

The Physical Object

Description:Online-Ressource : v.: digital

Edition Identifiers

ISBN:9780387262826, 0387262822, 9780387262833, 0387262830
DOI:10.1007/b137303
oclc:ocn846143856
LC Classification:RC268.5
Dewey Decimal:610

Subjects

Aufsatzsammlung Cancérologie Carcinogenese Chemokine cytokines Entzündung Inflammation Inflammation -- therapy Krebs Laboratories Médecine Médecine -- Laboratoires Medical laboratories Medical Oncology Medicine Medicine -- Public Health medicines (material) neoplasms Neoplasms -- etiology Nuklearfaktor Kappa B