The lung: development, aging and the environment

The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the "normal” and "disease” cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological fe.

Front Cover; The Lung; Copyright; Contents; Contributors; Introduction; Part I -- Critical Events in Normal Development and Aging; Chapter 1 -- Lung Progenitor Cell Specification and Morphogenesis; INTRODUCTION; ONSET OF LUNG DEVELOPMENT; BRANCHING MORPHOGENESIS; ESTABLISHMENT OF PROXIMAL-DISTAL CELL FATE AND DIFFERENTIATION; CONCLUSIONS; REFERENCES; Chapter 2 -- Development of Airway Epithelium; INTRODUCTION; DIFFERENCES IN PHENOTYPIC EXPRESSION IN ADULTS; OVERALL DEVELOPMENT OF AIRWAYS; SUBMUCOSAL GLANDS; EPITHELIAL DIFFERENTIATION; REGULATION OF DIFFERENTIATION; REFERENCES.

Chapter 3 -- Development of the Innervation of the Lower Airways: Structure and FunctionINTRODUCTION; ANATOMY, MORPHOLOGY, AND DISTRIBUTION IN THE PRENATAL LUNG; ANATOMY, MORPHOLOGY, AND DISTRIBUTION IN THE POSTNATAL LUNG; ONTOGENY AND REFLEX CONTROL OF AIRWAY SMOOTH MUSCLE: FUNCTIONAL CONSEQUENCES; MUSCARINIC RECEPTORS IN THE LUNG; ACKNOWLEDGMENTS; REFERENCES; Chapter 4 -- The Formation of Pulmonary Alveoli; INTRODUCTION; STAGES OF LUNG DEVELOPMENT; PARACRINE SIGNALING TO EPITHELIAL CELLS; DEVELOPMENT OF THE ALVEOLAR INTERSTITIUM; CONCLUSIONS; ACKNOWLEDGEMENTS; REFERENCES.

Chapter 5 -- Pulmonary Vascular …