The resolution revolution: recent advances in cryoEM

by Crowther, R. A., (Roy A.)

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Title Statements

Full title :The resolution revolution : recent advances in cryoEM / edited by R.A. Crowther.

Edition Statements

Publication Date:2016.

Publication Statements

Publisher(s):Academic Press is an imprint of Elsevier
Place of Publication:Cambridge, MA
Language:eng
Publication Date:2016.

Notes

VERSEMENT EN LOT.

The Physical Object

Description:1 ressource en ligne.

Edition Identifiers

ISBN:9780128054352, 0128054352
oclc:on1083984602
LC Classification:QH225
Dewey Decimal:570.28/2

Front Cover; The Resolution Revolution: Recent Advances In cryoEM; Copyright; Contents; Contributors; Preface; References; Chapter One: Direct Electron Detectors; 1. Introduction; 2. Past; 3. Present; 3.1. Practical Advice for the User; 4. Future; References; Chapter Two: Specimen Behavior in the Electron Beam; 1. Introduction; 2. High-Energy Electrons Are a Form of Ionizing Radiation as Well as Being a Form of Short-Wavelength Radiation That Can B ... ; 2.1. Electron-Scattering Events Can Be Either Elastic or Inelastic.

2.2. Energy Is Deposited in the Specimen as a Result of Inelastic Scattering2.3. Values of the Linear Energy Transfer (LET) Can Be Used to Estimate the Energy Deposited; 3. Biological Molecules Become Structurally Damaged When Irradiated; 3.1. There Is a Large Literature of Radiation Chemistry and Radiation Biology; 3.2. Fading of Diffraction Patterns Is a Convenient Indicator of Structural Damage; 3.3. Some Residues in Proteins Are Especially Sensitive to Radiation Damage; 3.4. Caging of Fragments and ``Trapping ́́of Radicals Results in Cryo-Protection: This Helps Only to a Limited Extent.

3.5. Radiation Sensitivity of Enzyme Activity: Implications for Dynamic St…