Toxicological Testing Handbook: Principles, Applications and Data Interpretation

Furnishing essential data on all areas of toxicity testing, this Second Edition provides guidance on the design and evaluation of product safety studies to help ensure regulatory acceptance. Every chapter highlights regulatory requirements specific to the United States, Europe, and Japan, and in addition to expanded information on data interpretation, hazard assessment, carcinogenicity studies, and Good Laboratory Practices, new chapters regarding safety pharmacology, juvenile studies, the health safety assessment of pharmaceuticals, and health assessment strategies in the food and cosmetic industry have been added to reflect changes to regulatory requirements. Toxicological Testing Handbook, Second Edition is a must-have reference for individuals responsible for assuring the safety of new pharmaceutical, biotechnical, and chemical products and materials.

Front Cover -- Preface -- Contents -- Contributors -- Chapter 1. Regulatory Toxicology Testing: Laboratories and Good Laboratory Practices -- Chapter 2. Laboratory Animals and In Vitro Test Systems Used in Regulatory Toxicology -- Chapter 3. Safety Pharmacology -- Chapter 4. Metabolism and Toxicokinetics -- Chapter 5. Toxicologic Pathology Assessment -- Chapter 6. Acute Toxicology -- Chapter 7. Multidose General Toxicology Studies -- Chapter 8. Genetic Toxicology -- Chapter 9. Carcinogenicity Studies -- Chapter 10. Juvenile Animal Toxicology Studies -- Chapter 11. Developmental and Reproductive Toxicology -- Chapter 12. Neurotoxicology Testing -- Chapter 13. Toxicological Assessment of the Immune System -- Chapter 14. Inhalation and Pulmonary Toxicity Studies -- Chapter 15. Cancer Risk Assessment of Environmental Agents: Approaches to the Incorporation and Analysis of New Scientific Information -- Chapter 16. Nonclinical Safety Testing of Pharmaceuticals -- Chapter 17. Health Risk Assessment Strategies in the Food and Cosmetic Industry -- Index -- Back Cover.