Transplantation immunology: methods and protocols

by Hornick, Philip Rose, Marlene L.

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Title Statements

Full title :Transplantation immunology : methods and protocols / edited by Philip Hornick, Marlene Rose.

Summary

Technical innovations in the laboratory over the past ten years have greatly improved our understanding of the immunological mechanisms of transplanted organ rejection. In Transplantation Immunology: Methods and Protocols, leading experts in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods of utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The areas of tolerance induction and reprogramming of the immune system are also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection. State of the art and highly practical, Transplantation Immunology: Methods and Protocols illuminates for clinicians and scientists-both newcomers and experts-the new world of detecting and monitoring patients' immunological responses to solid organ transplantation.

Edition Statements

Publication Date:©2006.

Publication Statements

Publisher(s):Humana Press
Place of Publication:Totowa, N.J
Language:eng
Publication Date:©2006.

The Physical Object

Description:1 online resource (x, 429 pages) : : illustrations

Edition Identifiers

ISBN:1588295443, 9781588295446, 9781597451222, 1597451223, 9781597450492, 1597450499, 1280832045, 9781280832048, 9786610832040, 6610832048
DOI:10.1385/1597450499.
oclc:ocn172734706
LC Classification:QR188.8
Dewey Decimal:617.9/5

Current status of renal transplantation / Christopher J. Callaghan and Andrew J. Bradley -- Current status of liver transplantation / Peter J. Friend and Charles J. Imber -- Current status of clinical islet cell transplantation / Jonathan R.T. Lakey, Mohammadreza Mirbolooki, and A.M. James Shapiro -- Current status of lung transplantation / Allan R. Glanville -- Chronic rejection in the heart / Philip Hornick and Marlene Rose -- Direct and indirect allorecognition / Philip Hornick -- HLA typing and its influence on organ transplantation / Stephene Sheldon and Kay Poulton -- Strategies for gene transfer to solid organs : viral vectors / Charlotte Lawson -- Nonviral vectors / Louise Collins -- Detection and clinical relevance of antibodies after transplantation / John D. Smith and Marlene Rose.

Reprogramming the immune system using antibodies / Luis Graca and Hermann Waldmann -- In vitro assays for immune monitoring in transplantation / Maria P. Hernandez-Fuentes and Alan Salama -- Proteomics and laser microdissection / Emma McGregor and Ayesha De Souza -- Real-time quantitative polymerase chain reaction in cardiac transplant research / Leanne E. Felkin, Ann B. Taegtmeyer, and Paul…

Subjects

Graft Rejection -- diagnosis Graft Rejection -- immunology Greffe (Chirurgie) -- Immunologie Laboratory Techniques and Procedures MEDICAL -- Surgery Organ Transplantation -- adverse effects Transplantation Immunology Transplantation, Homologous; immunology