Tumor immunology

by Schreiber, Robert

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Title Statements

Full title :Tumor immunology / edited by Robert D. Schreiber, Washington University School of Medicine, St. Louis, Missouri, USA.

Summary

This volume focuses on the fields of cancer immunology and cancer immunotherapy. It looks at the important role of immunity throughout the entire cancer cycle - from unresolved inflammation promoting cellular transformation, to the roles of innate and adaptive immunity in the cancer immunoediting process that both protects the host against cancer outgrowth and shapes cancer immunogenicity, to the observation that cancer can co-opt the complex machinery that evolved to prevent autoimmunity and use it to its own advantage by inducing, in otherwise immunocompetent hosts, a state of tumour-specific immune unresponsiveness that favors cancer expansion over cancer patient survival. Thus the field has undergone a major paradigm shift in its thinking about the interaction of the immune system with developing and established tumors. The immune system is seen as a key player in the complex interactions that lead to the fate decisions of cancer development and cancer control. The stage is set for a generation of novel and effective cancer immunotherapies that in some cases can promote extraordinary, durable responses in cancer patients that have never been seen before. Cancer immunotherapy has become a reality and to many has become the fourth pillar of cancer therapy (together with surgery, chemotherapy and radiation therapy). There are many critical questions remaining about cancer immunotherapy and finding answers to these is explored in this thematic volume.

Edition Statements

Publication Date:2016

Publication Statements

Publisher(s):Elsevier Academic Press
Place of Publication:Amsterdam
Language:eng
Publication Date:2016

The Physical Object

Description:xiii, 318 pages, 6 unnumbered pages of plates : : illustrations ; : 24 cm

Edition Identifiers

ISBN:9780128051566, 0128051566
oclc:ocn930255385
LC Classification:QR188.6
Dewey Decimal:616.9/94/079

1. Mouse models of tumor immunotherapy -- 2. The role of neoantigens in naturally occurring and therapeutically induced immune responses to cancer -- 3. Tumor and host factors controlling antitumor immunity and efficacy of cancer immunotherapy -- 4. Immune contexture, immunoscore, and malignant cell molecular subgroups for prognostic and theranostic classifications of cancers -- 5. Advances in therapeutic cancer vaccines -- 6. Combinatorial cancer immunotherapies -- 7. Adoptive T-cell therapy for cancer.

Subjects

Cancer -- Traitement Cancer -- Treatment Cellular therapy -- Research T cells -- Research Thérapie cellulaire -- Recherche Tumeurs -- Immunologie Tumors -- Immunological aspects