Williams hematology

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. It is acknowledged worldwide as the leading hematology resource, with editors who are internationally regarded for their research and clinical achievements and authors who are luminaries in their fields. The Ninth Edition of Williams Hematology is extensively revised to reflect the latest advancements in basic science, translational pathophysiology, and clinical practice. In addition to completely new chapters, it features a full-color presentation that includes 700 photographs, 300 of which are new to this edition, and 475 illustrations. Recognizing that blood and marrow cell morphology is at the heart of diagnostic hematology, informative color images of the relevant disease topics are conveniently integrated into each chapter, allowing easy access to illustrations of cell morphology important to diagnosis. Comprehensive in its depth and breath, this go-to textbook begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine.

[Contents] Initial approach to the patient: History and physical examination. -- Examination of blood cells. -- Examination of the marrow. -- Consultative Hematology. -- Structure of the marrow and hematopoietic microenvironment. -- The organization and structure of lymphoid tissues. -- Hematology of the fetus and newborn. -- Hematology during pregnancy. -- Hematology in older persons. -- Genetic principles. -- Genomics. -- Epigenetics. -- Cytogenetic and Genetic Abnormalities. -- Metabolism of Hematological Neoplastic Cells. -- Apoptosis and Autophagy. -- Cell cycle regulation and hematological disorders. -- Signal transduction pathways. -- Hematopoietic stem cells, progenitors, and cytokines. -- The inflammatory response. -- Innate immunity. -- Adaptive immunity. -- Pharmacology and toxicity of antineoplastic drugs. -- Hematopoietic stem cell transplantation. -- Treatment of infections in the immunocompromised host. -- Antithrombotic therapy. -- Immune cell therapy. -- Vaccine therapy. -- Therapeutic apheresis: indications, efficacy, and complications. -- Gene transfer for therapy. -- Regenerative Medicine: Multipotential cell therapy for tissue replacement. -- Structure and Com…