Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug devel…
Using well-documented case studies from drug development projects over the past decade, this handbook and ready reference demonstrates the current importance and future potential of natural products as drug precursors, highlighting the lessons learned and pointing to future dire…
In contrast to previous texts focusing on either computational, structural or synthetic methods, this one-of-a-kind guide integrates all three skill sets for a complete picture of contemporary structure-based design. As a result, this practical book demonstrates how to develop a…