This text details essential components of performing simulation for designing clinical trials via pharmacokinetic-pharmacodynamic modelling. It offers a range of applications for optimizing sampling strategies, selecting dosage and predicting drug efficacy and side-effects.
This book examines the background, construction, evaluation, and execution of simulation models for optimizing the design of clinical trials. -- book cover.
Adaptive design theory and implementation using SAS and R
by Chang, Mark
fromChapman & Hall
Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using S…