This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel's first experiments to genome-wide association studies, the book describes how genetic informa…
"This book shows why contests over intellectual property rights and access to affordable medicines emerged in the 1990s and how they have been resolved so far. It argues that the current arrangement mainly ensures wealth for some rather than health for all, and points to broader…
The multidisciplinary science of chemical proteomics studies how small molecules of synthetic or natural origin bind to proteins and modulate their function. In Chemical Proteomics: Methods and Protocols, expert researchers in the field provide key techniques to investigate chem…
"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehens…
"This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehens…
During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observatio…
Anoxia defines the lack of free molecular oxygen in an environment. In the presence of organic matter, anaerobic prokaryotes produce compounds such as free radicals, hydrogen sulfide, or methane that are typically toxic to aerobes. The concomitance of suppressed respiration and …
The development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and curre…
"In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthet…
Network-based representations have become pervasive in most fields in biology. Bacterial Molecular Networks: Methods and Protocols provides authoritative descriptions of various experimental and computational methods enabling the characterization and analysis of molecular intera…
The rapid expansion of synthetic biology is due to the design and construction of synthetic gene networks that have opened many new avenues in fundamental and applied research. Synthetic Gene Networks: Methods and Protocols provides the necessary information to design and constr…
Named a ""Choice Outstanding Academic Title"" for 2007 and an ""AJN Book of the Year"". The award-winning Encyclopedia of Nursing Research, now in its third edition, is the comprehensive resource for tracking developments in the field. With over 20 new areas of research, and met…
Dr. Chen shares his almost 40 years of clinical genetics practice in a comprehensive pictorial atlas of almost 250 genetic disorders, malformations, and malformation syndromes. The author provides a detailed outline for each disorder, describing its genetics, basic defects, clin…
Drug addiction remains one of the most important public health problems in western societies and is a rising concern for developing nations. Over the past 3 decades, experimental research on the neurobiology and psychology of drug addiction has generated a torrent of exciting da…
Synaptic Mechanisms in the Auditory System will provide a basic reference for students, clinicians, and researchers on how synapses in the auditory system function to encode acoustic signals. These mechanisms are the groundwork for all auditory processing, and understanding them…
The International Society for Systems Biology (ISSB) is a society aimed at advancing world-wide systems biology research by providing a forum for scientific discussions and various academic services. The ISSB helps coordinate researchers to form alliances for meeting the unique …
Molecular networks provide descriptions of the organization of various biological processes, including cellular signaling, metabolism, and genetic regulation. Knowledge on molecular networks is commonly used for systems level analysis of biological function; research and method …
The incidence of fungal infections increases with the increase in antibiotic usage and increasing immunosuppressed populations. There is no longer only one antifungal agent and the response of fungi to various agents is not always predictable. The need for standardized antifunga…
Unique coverage of proteomic and glycomic approaches to better distinguish highly dangerous pathogens, as well as using these to explore novel treatment and prevention options. The editors and authors are either part of a specialized European network initiated to develop fast an…
Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-…
