Antibiotics: challenges, mechanisms, opportunities
"Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membran…
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- Full title :Antibiotics : challenges, mechanisms, opportunities / by Christopher Walsh, ChEM-H Institute, Stanford University and Timothy Wencewicz, Department of Chemistry, Washington University in St. Louis.
Summary
"Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sourcFes. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets.This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics." -- Publisher's description.
Read More ↓Edition Statements
- Publication Date:©2016
Publication Statements
- Publisher(s):ASM Press
- Place of Publication:Washington, DC
- Language:eng
- Publication Date:©2016
The Physical Object
- Description:x, 477 pages : : illustrations (some color) ; : 26 cm
Edition Identifiers
- ISBN:9781555819309, 1555819303
- oclc:ocn931476697
- LC Classification:RM267
- Dewey Decimal:615.3/29
Table of Contents
Challenges for antibiotics -- Mechanisms: Antibiotic action by bacterial target class -- Mechanisms: Bacterial resistance to antibiotics -- Mechanisms: Antibiotic biosynthesis -- Opportunities.
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