Bioactive carboxylic compound classes: pharmaceuticals and agrochemicals

Following the successful and proven concept used in "Bioactive Heterocyclic Compound Classes" by the same editors, this book is the first to present approved pharmaceutical and agrochemical compounds classified by their carboxylic acid functionality in one handy volume. Each of the around 40 chapters describes one or two typical syntheses of a specific compound class and provides concise information on the history of development, mode of action, biological activity and field of application, as well as structure-activity relationships. In addition, similarities and differences between pharmaceuticals and agrochemicals are discussed in the introduction. Written by a team of experts in the field, this is a useful reference for researchers in academia and chemical or pharmaceutical companies working in the field of total synthesis and natural product chemistry, drug development, and crop protection research.

1. Introduction: Different Roles of Carboxylic Acid Functions in Pharmaceutical and Agrochemical Active Ingredients; ; PART I: PHARMACEUTICALS; 2. Angiotensin II Receptor Antagonistic Acids in Cardiovascular Disease; 3. Anti-inflammatory Corticosteroid Esters; 4. Non-steroidal Anti-Inflammatory Drugs (NSAIDs); 5. Anticholinergic Muscarinic Receptor Antagonist Esters; 6. Oxazolidinone Amide Antibiotics; 7. Prostaglandine Analog Esters and Amides for the Treatment of Glaucoma; 8. 5a-Reductase Inhibiting Amides; 9. Analgesic and Anesthetic Amides; 10. Fibrate Acids and Esters in the Treatment of Hyperlipidemia; 11. Dipeptidyl Peptidase-4 (DPP-4) Inhibiting Amides; 12. NS5B Polymerase Inhibiting Esters (Sovaldi); 13. Dimethyl Fumarate for the Treatment of Multiple Sclerosis; 14. Acids for the Treatment of Neuropathic Pain, Anxiety Disorder, and Fibromyalgia (Pregabalin, Lyrica); 15.

Factor Xa Inhibiting Amides (Rivaroxaban, Xarelto); 16. Thrombin Inhibiting Esters and Acids; 17. Neuraminidase Inhibiting Esters and Acids; 18. Carboxylic Acids as Antihistamines; 19. Norepinephrine-Dopamine Reuptake Inhibiting Esters (Ndris); 20. Statin HMG Coa Reductase Inhibiting Acids as Hypolipidemi…