Catalytic RNA

by Soukup, Garrett A.

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Title Statements

Full title :Catalytic RNA / edited by Garrett A. Soukup.

Edition Statements

Publication Date:2013.

Publication Statements

Publisher(s):Elsevier Science
Place of Publication:Burlington
Language:eng
Publication Date:2013.

Notes

4.1.2. A bridging Mg2+ ion maintains rigid coordination patterns that stabilize in-line attack conformations.

The Physical Object

Description:255 pages

Edition Identifiers

ISBN:9780123812865, 0123812860
oclc:ocn940659856
LC Classification:QP623.5
Dewey Decimal:572.886

Front Cover; Catalytic RNA; Copyright; Contents; Contributors; Preface; Chapter One: The Hammerhead Ribozyme: Structure, Catalysis, and Gene Regulation; 1. Discovery and Context; 1.1. Biological context; 1.2. A prototype ribozyme; 2. The Minimal Sequence; 2.1. Enzymology; 2.1.1. Rate enhancement; 2.1.2. Metal ions and catalysis; 2.1.3. Acid-base chemistry; 2.1.4. Kinetics; 2.2. Crystal structure; 2.3. Experimental discord; 3. The Full-Length Sequence; 3.1. Biological context; 3.2. Enzymology; 3.3. Crystal structure; 3.4. Resolution of experimental discord; 3.5. Mechanistic proposals.

4. Hammerhead Ribozymes in Mammalian Gene RegulationReferences; Chapter Two: Bridging the Gap Between Theory and Experiment to Derive a Detailed Understanding of Hammerhead Ribozyme Cata ... ; 1. Introduction; 2. A Metal Ion Story with a Happy Ending; 2.1. Discrepancies between biochemical and crystallographic data; 2.1.1. Positions of the A9 and scissile phosphates were inconsistent with interpretations from thio/rescue effect experiments; 2.1.2. Crystal structures did not provide straightforward interpretation of mutagenesis data.

2.1.3. Lack of structural support for general acid and base candida…