Chromatographic methods development

by Knott, Laila Webster, Gary K.

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Title Statements

Full title :Chromatographic methods development / edited by Gary K. Webster, Laila Knott.

Summary

This book is a comprehensive compilation of modern and cutting-edge chromatographic techniques written by pharmaceutical industry experts, academics, and vendors in the field. This book is an inclusive guide to developing allchromatographic methods (such as liquid chromatography and gas chromatography). It covers modern techniques for developing methods using chromatographic development software, requirements for validations, discussion on orthogonality, and how to transfer methods from HPLC to UHPLC. The text introduces some newer techniques that are heavily employed by chemists analyzing proteins and RNAi, as well as novel techniques such as counter current chromatography. This book is valuable for both the novice starting out in undergraduate labs and those who are new to the pharmaceutical industry and is a useful reference for seasoned analysts.

Edition Statements

Publication Date:©2020

Publication Statements

Publisher(s):Jenny Stanford Publishing
Place of Publication:Singapore
Language:eng
Publication Date:©2020

Notes

Includes index.

The Physical Object

Description:1 online resource (xxiii, 542 pages) : : illustrations

Edition Identifiers

ISBN:9780429510397, 042951039X, 9780429201721, 0429201729, 9780429517259, 0429517254, 9780429513824, 0429513828
oclc:on1126217309
LC Classification:QP519.9.C47
Dewey Decimal:543/.8

Introduction -- a lesson learned from UHPLC. Software for Chromatographic method development. Flash Chromatography Method Development. Orthonganality in Column chromatography. Unified approach to reverse phase and normal phase chromatography. Polysaccharide derived chiral stationary phases for the separation of enantiomers. Chiral chromatography: Method development. Aqueous Normal phase chromatography using Type-C silica columns. Ion Chromatography Columns. Ion chromatography -- Method development. Fundamentals, properties, and applications of stationary phases for gas chromatography method development. GC method Development. Method Transfer from HPLC to UHPLC. Small Molecule Pharmaceutical impurities Test Method Validation: Precision Acceptance Criteria. Method Development Strategies for Ion Exchange Chromatography Using pH Gradient Separation for mAbs. Antibody Drug Conjugates (ADCs) and Other Complex Bio-Pharmaceuticals. Size exclusion chromatography method development for theraputic proteins. Ionic liquids and counter current chromatography: Is this the future of process purifications?