Chromosomal instability and aging

Chromosomal instability and aging: basic science and clinical implications

by Hisama, Fuki M. Martin, George M. Weissman, Sherman M.

Type Book
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This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability and ageing. It includes in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage.

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Title Statements

  • Full title :Chromosomal instability and aging : basic science and clinical implications / ed. by Fuki M. Weissman, George M. Martin

Summary

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability and ageing. It includes in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage.

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Edition Statements

  • Publication Date:2003

Publication Statements

  • Publisher(s):Marcel Dekker Inc
  • Place of Publication:New York
  • Language:eng
  • Publication Date:2003

Notes

This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability and ageing. It includes in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of ageing processes and age-related disease, including cancer development.

The Physical Object

  • Description:579 s. : : illustrations

Edition Identifiers

  • ISBN:0824708563, 9780824708566
  • oclc:ocn472094444
  • Dewey Decimal:612.67

Table of Contents

Introduction to the pathobiology of ageing; overview of chromosomal instability and ageing mechanisms. Replicative senescence, telomere regulation and chromosomal instability: cell senescence; telomere shortening and replicative ageing; telomere regulation in eukaryotic cells. Human premature ageing and chromosomal instability syndromes: Werner syndrome; Bloom syndrome -- genetic, cellular and molecular features as compared to Werner syndrome; molecular biology of Rothmund-Thomson syndrome; molecular biology of Rothmund-Thomson syndrome. Ageing in model organisms: genomic instability and yeast ageing; the genetics of ageing in the nematode Caenorhabditis elegans; ageing, somatic maintenance, and genome stability Drosophilia melanogaster.

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Subjects

Aging -- Genetic aspects Aging -- Molecular aspects Cells -- Aging Cellular Senescence Cellules -- Vieillissement Chromosomes Vieillissement -- Aspect génétique Vieillissement -- Aspect moléculaire

Writers

Hisama, Fuki M. Martin, George M. Weissman, Sherman M.

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