Clinical molecular diagnostics

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Degree of Nonlinearity.

Intro -- Foreword -- Coordinators -- Preface -- Acknowledgments -- Contents -- About the Editors and Contributors -- About the Editors -- Editorial Board -- Contributors -- Part I: Principles of Clinical Molecular Diagnostics -- 1: Molecules of Disease and Their Detection Methods -- 1.1 Overview -- 1.2 Molecular Mechanism of Diseases -- 1.3 Nucleic Acid Detection Methods -- 1.3.1 Nucleic Acid Amplification Technology -- 1.3.2 Sequencing Technology -- 1.3.3 Nucleic Acid Hybridization Technology -- 1.3.4 Chip Technology -- 1.3.5 Biosensing Technology -- 1.4 Protein Detection Methods

1.4.1 Spectrum Technology -- 1.4.2 Protein Chip Technology -- 1.4.3 Labeled Immunoassay -- 1.4.4 Mass Spectrometric Technique -- 1.5 Future Trends -- References -- 2: Assay Performance Evaluation -- 2.1 Precision -- 2.1.1 Terminology and Definitions -- 2.1.2 Overview of the Precision Evaluation Process (Fig. 2.1) -- 2.1.3 Features of the EP5-A2 Program -- 2.1.4 EP5-A2 Experimental Protocol and Requirements -- 2.1.4.1 Experimental Preparation -- Experimental Sample -- 2.1.4.2 Experimental Method -- 2.1.4.3 Quality Control -- 2.1.5 Data Collection, Processing, and Statistical Analysis

2.1.5.1 Experimenta…