Clinical Trials in Neurology

Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.

1 Ethical Considerations -- 2 Assessment Measures and Clinical Scales -- 3 Ethics, Outcome Variables and Clinical Scales: The Clinician's Point of View -- 4 The Cochrane Collaboration Reviews in Neurology -- 5 Drug Development Stages -- 6 Drug Regulatory Requirements in the United Kingdom and Europe -- 7 Drug Regulatory Requirements in the United States -- 8 Quality Control and Data Monitoring: A Guide To Good Clinical Practice -- 9 Statistical Issues in Clinical Trials in Neurology -- 10 Analysis of Results: Statistical Principles -- 11 Survival Analysis -- 12 The Intention-to-Treat Principle for Clinical Trials -- 13 Statistical Analysis of Repeated-Measures Data with Drop-outs -- 14 The Role of Meta-analyses in Clinical Research: Uses and Limitations -- 15 Outcome Variables in Dementia Trials: Conceptual and Practical Issues -- 16 Dementia: Trial Design and Experience with Large Multicentre Trials -- 17 Cerebrovascular Disease: Basic Designs, Sample Sizes and Pitfalls -- 18 Clinical Trials in Stroke Prevention in North America -- 19 Cerebrovascular Disease: Experience Within Large Multicentre Trials -- 20 Epilepsy: Ethics, Outcome Variables and Clinical Scales -- 21 Epilepsy: B…