Combinatorial chemistry and technology: principles, methods, and applications

Provides comprehensive coverage of the current combinatorial methodologies and technologies employed for the design, synthesis, and screening of molecular "libraries." Features assessments of computer-assisted approaches to guiding library synthesis. Designed to satisfy the demand to create, produce in high yield and purity, and rapidly screen huge numbers of molecules.

Combinatorial chemistry and combinatorial technologies: principles and applications / Giorgio Fassina -- Synthesis and characterization of peptide libraries / Menotti Ruvo -- Solid-phase synthesis of organic libraries / Eduard R. Felder -- Resins, linkers, and reactions for solid-phase synthesis of organic libraries / Eduard R. Felder -- Solution-phase combinatorial libraries of small organic molecules / Rafael Ferritto -- Direct deconvolution techniques for pool libraries of small organic molecules / Pierfausto Seneci -- Encoding techniques for pool libraries of small organic moleucles / Pierfausto Seneci -- Analytical characterization of synthetic organic libraries / Nikolai Sepetov -- Automation in combinatorial chemistry / Valery V. Antonenko -- Key ingredients for efficient high-throughput screening / Lucia Carrano -- Computational aspects of combinatorial chemistry / Valerie J. Gillet -- Biological libraries / Maria Dani -- Peptide display libraries: design and construction / Maria Dani -- Making and selecting from phage antibody libraries / Andrew Bradbury -- Biopanning / Giovanna Palombo -- Globular oligonucleotide screening via the SELEX process: aptamers as high-affinity…