Computer-aided antibody design
by Kuroda, Daisuke Tsumoto, Kouhei
This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes…
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- Full title :Computer-aided antibody design / edited by Kouhei Tsumoto and Daisuke Kuroda.
Summary
This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Read More ↓Edition Statements
- Publication Date:2023
Publication Statements
- Publisher(s):Humana Press
- Place of Publication:New York, NY
- Language:eng
- Publication Date:2023
The Physical Object
- Description:xiv, 491 pages : : illustrations (chiefly color) ; : 26 cm.
Edition Identifiers
- ISBN:9781071626085, 1071626086
- oclc:on1312149685
- LC Classification:QR182.2.I46
Table of Contents
Antibody sequence and structure analyses using IMGTª: 30 years of immunoinformatics -- Structural Classification of CDR-H3 in Single-Domain VHH Antibodies -- Computational modelling of Antibody and T Cell receptor (CDR3 loops) -- Molecular dynamics simulation for investigating antigen-antibody interaction -- Molecular Dynamics Methods for Antibody Design -- Probing antibody dynamics with geometric simulations -- PITHA: a webtool to predict immunogenicity for humanized and fully human therapeutic antibodies -- Thermal Stability Estimation of Single Domain Antibodies Using Molecular Dynamics Simulations -- Assessing and engineering antibody stability using experimental and computational methods -- In Silico Prediction Method for Protein Asparagine Deamidation -- Structure-based Optimization of Antibody-Based Biotherapeutics for Improved Developability: A Practical Guide for Molecular Modelers -- B-cell epitope predictions using computational methods -- Computational Epitope Prediction and Design for Antibody Development and Detection -- Information-driven antibody-antigen modelling with HADDOCK -- Structural modeling of adaptive immune responses to infection -- Protein-Protein Inter…
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