Computer-aided antibody design

by Kuroda, Daisuke Tsumoto, Kouhei

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Title Statements

Full title :Computer-aided antibody design / edited by Kouhei Tsumoto, Daisuke Kuroda.

Summary

This volume details state-of-the- art methods on computer-aided antibody design. Chapters guide readers through information on antibody sequences and structures, modeling antibody structures and dynamics, prediction and optimization of biological and biophysical properties of antibodies, prediction of antibody-antigen interactions, and computer-aided antibody affinity maturation and beyond. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Computer-Aided Antibody Design aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. Chapter 2 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Edition Statements

Publication Date:©2023

Publication Statements

Publisher(s):Humana Press
Place of Publication:New York, NY
Language:eng
Publication Date:©2023

Notes

Includes index.

The Physical Object

Description:1 online resource (xiv, 491 pages) : : illustrations (chiefly color).

Edition Identifiers

ISBN:9781071626092, 1071626094
DOI:10.1007/978-1-0716-2609-2
oclc:on1350841938
LC Classification:QR182.2.I46
Dewey Decimal:616.07/90285

Antibody sequence and structure analyses using IMGTª: 30 years of immunoinformatics -- Structural Classification of CDR-H3 in Single-Domain VHH Antibodies -- Computational modelling of Antibody and T Cell receptor (CDR3 loops) -- Molecular dynamics simulation for investigating antigen-antibody interaction -- Molecular Dynamics Methods for Antibody Design -- Probing antibody dynamics with geometric simulations -- PITHA: a webtool to predict immunogenicity for humanized and fully human therapeutic antibodies -- Thermal Stability Estimation of Single Domain Antibodies Using Molecular Dynamics Simulations -- Assessing and engineering antibody stability using experimental and computational methods -- In Silico Prediction Method for Protein Asparagine Deamidation -- Structure-based Optimization of Antibody-Based Biotherapeutics for Improved Developability: A Practical Guide for Molecular Modelers -- B-cell epitope predictions using computational methods -- Computational Epitope Prediction and Design for Antibody Development and Detection -- Information-driven antibody-antigen modelling with HADDOCK -- Structural modeling of adaptive immune responses to infection -- Protein-Protein Inter…