Coronaviruses

by Ziebuhr, John

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Title Statements

Full title :Coronaviruses / edited by John Ziebuhr.

Edition Statements

Publication Date:©2016.

Publication Statements

Publisher(s):Academic Press
Place of Publication:Cambridge, MA
Language:eng
Publication Date:©2016.

Notes

Includes index.

The Physical Object

Description:1 online resource

Edition Identifiers

ISBN:9780128051153, 0128051159
oclc:ocn959951527
LC Classification:QR399
Dewey Decimal:579.2/56

Front Cover; Coronaviruses; Copyright; In Memoriam; Contents; Contributors; Preface; Chapter One: Supramolecular Architecture of the Coronavirus Particle; 1. Introduction; 2. Virion Structure and Durability; 3. Viral Proteins in Assembly and Fusion; 3.1. Membrane Protein; 3.2. Nucleoprotein; 3.3. Envelope Protein; 3.4. Spike Protein; 4. Evolution of the Structural Proteins; References; Chapter Two: Coronavirus Spike Protein and Tropism Changes; 1. Introduction; 2. Structure of the Coronavirus S Protein; 2.1. Structure of the S1 Subunit; 2.2. Structure of the S2 Subunit.

3. Spike-Receptor Interactions3.1. Different Domains Within S1 May Act as RBD; 3.2. CoV Protein Receptor Preference; 4. S Protein Proteolytic Cleavage and Conformational Changes; 5. Tropism Changes Associated with S Protein Mutations; 5.1. S1 Receptor Interactions Determining Tropism; 5.1.1. S1 NTR Changes; 5.1.2. S1 CTR Changes; 5.2. Changes in Proteolytic Cleavage Site and Other S2 Mutations Associated with Altered Tropism; 5.2.1. Changes in Proteolytic Cleavage Sites; 5.2.2. Other S2 Mutations Associated with Altered Tropism; 6. Concluding Remarks; Acknowledgments; References.

Chapter Three: The Nonstructural …