Developmental toxicology: methods and protocols

by Hansen, Jason M.,, Ph.D Winn, Louise M.

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Title Statements

Full title :Developmental toxicology : methods and protocols / edited by Jason M. Hansen, Louise M. Winn.

Summary

"This thorough edition explores numerous methodological approaches that can be extremely informative for our understanding of the developmental toxicant mechanisms, characterization of developmental outcomes, and development of potential interventions that are clinically relevant. Presenting both staple and state-of-the-art approaches, the book focuses on numerous cellular models (induced pluripotent stem cells, neural crest culture, etc.), some less frequently used but important animal models (chick, zebrafish), in vitro approaches using whole embryos (rat, mouse and rabbit), and specific outcome methodologies to assess changes on the morphological to molecular level. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and expert implementation advice that allows for smooth processes in the lab. Authoritative and practical, Developmental Toxicology: Methods and Protocols, Second Edition serves as an ideal aid to support further investigation into the specific mechanisms and outcomes of developmental exposures." - Prové de l'editor.

Edition Statements

Publication Date:2019
Edition:2nd ed. 2019

Publication Statements

Publisher(s):Imprint: Humana, Springer New York
Place of Publication:New York, NY
Language:eng
Publication Date:2019

The Physical Object

Description:1 recurs en línia (XI, 436 pàgines) : : 155 il·lustracions, 104 il·lustracions en color

Edition Identifiers

ISBN:9781493991822, 1493991825
DOI:10.1007/978-1-4939-9182-2
oclc:on1139471423

Conté: In Vitro Models in Developmental Toxicology -- Use of Primary Mouse Embryonic Fibroblasts in Developmental Toxicity Assessments -- Induced Pluripotent Stem Cells (iPSCs) in Developmental Toxicology -- Neural Crest Cell Models of Development and Toxicity: Cytotoxicity Assay Using Human Pluripotent Stem Cell-Derived Cranial Neural Crest Cell Model -- Micromass Methods for the Evaluation of Developmental Toxicants -- The Murine Limb Bud in Culture as an In Vitro Teratogenicity Test System -- Embryonic Mid-Facial Palatal Organ Culture Methods in Developmental Toxicology -- Ex Vivo Fetal Whole Ovarian Culture Model: An Essential Tool for Studies in Reproductive Toxicology and Pharmacology -- Hepatotoxicity in Zebrafish Larvae -- Drosophila as a Model for Developmental Toxicology: Using and Extending the Drosophotoxicology Model -- The Chicken Embryo as a Model in Developmental Toxicology -- The Xenopus tropicalis Model for Studies of Developmental and Reproductive Toxicity -- Mouse Whole Embryo Culture -- Rat Whole Embryo Culture -- Rabbit Whole Embryo Culture -- Genome Editing in Zebrafish Using CRISPR-Cas9: Applications for Developmental Toxicology -- Identifying Toxicant-Inte…