Dopamine: endocrine and oncogenic functions

Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

Chapter 1: Homeostasis of dopamine. Chapter 2: Dopamine receptors and their signaling. Chapter 3: Anatomical and endocrine aspects of brain dopamine. Chapter 4: Attributes of peripheral dopamine. Chapter 5: Renal and cardiovascular functions of dopamine. Chapter 6: Digestive and metabolic actions of dopamine. Chapter 7: Dopamine and hematopoiesis. Chapter 8: Regulation of reproduction by dopamine. Chapter 9: Cutaneous actions of dopamine. Chapter 10: Dopamine and tumorigenesis in reproductive tissues. Chapter 11: Dopamine, hematologic and GI-related cancers. Chapter 12: Actions of dopamine on other cancers. Summary and Perspectives