Endocrine disruption and human health

Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human healthPresents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human healthOffers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations.

Overview and scope: 1. What are the endocrine disrupters and where are they found? / Philippa D. Darbre -- 2. How could endocrine disrupters affect human health? / Philippa D. Darbre. Mechanisms and assay systems: 3. Disrupters of estrogen action and synthesis / Philippa D. Darbre -- 4. Disruptors of androgen action and synthesis / J. Thomas Sanderson -- 5. Disrupters of thyroid hormone action and synthesis / Jenny Odum -- 6. Disruption of other receptor systems: progesterone and glucocorticoid receptors, peroxisome preliferator-activated receptors, pregnane X receptor, and aryl hydrocarbon receptor / Philippa D. Darbre -- 7. Nonmonotonic responses in endocrine disruption / Laura N. Vendenburg. Concerns for human health: 8. Endocrine disruption and female reproductive health / Philippa D. Darbre -- 9. Endocrine disruption and male reproductive health / Philippa D. Darbre -- 10. Endocrine disruption and cancer of reproductive tissues / Philippa D. Darbre, Graeme Williams -- 11. Endocrine disruption of thyroid function: chemicals, mechanisms and toxicopathology / Catherine Sutcliffe, Philip W. Harvey -- 12. Endocrine disruption of adrenocortical function / Philip W. Harvey -- 13. En…