G protein-coupled receptors in drug discovery

by Leifert, Wayne R.

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Title Statements

Full title :G protein-coupled receptors in drug discovery / edited by Wayne R. Leifert

Edition Statements

Publication Date:2009

Publication Statements

Publisher(s):Humana Press
Place of Publication:New York
Language:eng
Publication Date:2009

The Physical Object

Description:XI, 376 Seiten : Illustrationen

Edition Identifiers

ISBN:1603273166, 1603273174, 9781603273169, 9781603273176
oclc:ocn836992189
LC Classification:QP552.G16
Dewey Decimal:612/.01575

New insights into GPCR function: implications for HTS / R.M. Eglen and T. Reisine -- Screening technologies for G proteincoupled receptors: from HTS to uHTS / M. De los Frailes and E. Diez -- GPCR signaling: understanding the pathway to successful drug discovery / C. Williams and S.J. Hill -- An overview on GPCRs and drug discovery: structurebased drug design and structural biology on GPCRs / K. Lundstrom -- Understanding the ligandreceptorG protein ternary complex for GPCR drug discovery / V.R. Ratnala and B. Kobilka -- Assay data quality assessment / H. Gubler -- Homology modeling of GPCRs / J. Simms [und weitere] -- GPCR expression using baculovirusinfected Sf9 cells / A.L. Aloia [und weitere] -- Radioligand binding assays: application of [(125)I]angiotensin II receptor binding / W.R. Leifert [und weitere] -- [35S]GTPgammaS binding in G proteincoupled receptor assays / T. Cooper, E.J. McMurchie and W.R. Leifert -- A timeresolved fluorescent lanthanide (Eu)GTP binding assay for chemokine receptors as targets in drug discovery / J. Labrecque, R.S. Wong and S.P. Fricker -- Use of the DiscoveRx Hit hunter cAMPII assay for direct measurement of cAMP in Gs and Gi GPCRs / J. Bradley a…

Subjects

Drug development Drug Discovery Drug receptors G proteins G proteins -- Receptors Laboratory Manual Laboratory manuals Ligands Manuels de laboratoire Médicaments -- Développement Protéines G -- Récepteurs Receptors, G-Protein-Coupled