Gene therapy for autoimmune and inflammatory diseases
by Chernajovsky, Yuti Robbins, Paul D.
This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery…
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- Full title :Gene therapy for autoimmune and inflammatory diseases / edited by Yuti Chernajovsky and Paul D. Robbins.
Summary
This book addresses the latest advances in viral and non-viral vectors, novel targets and methods for the treatment of autoimmune and inflammatory disease with a main focus in pre-clinical testing with up to date clinical trials. The first section of the book deals with current research approaches for treating rheumatoid arthritis, osteoarthritis, diabetes, Crohn's disease, multiple sclerosis, Sjögrens syndrome, cystic fibrosis, myositis and lupus. The second section is devoted to cell delivery and vector development including plasmids, regulated promoters, adenovirus gutted vectors and adeno-associated vectors. All chapters are summarised by leaders in these fields. A must read for post graduate students, clinical and non-clinical researchers in the disciplines of immunology, molecular medicine, pharmacology, gene and cell-mediated therapy.
Read More ↓Edition Statements
- Publication Date:©2010.
Publication Statements
- Publisher(s):Birkhäuser
- Place of Publication:Basel
- Language:eng
- Publication Date:©2010.
The Physical Object
- Description:1 online resource (xi, 239 pages) : : illustrations
Edition Identifiers
- ISBN:9783034601658, 3034601654, 9783034601641, 3034601646
- DOI:10.1007/978-3-0346-0165-8
- oclc:ocn701718733
- LC Classification:RC600
- Dewey Decimal:616.978042695
Table of Contents
Cover -- Table of Contents -- List of Contributors -- Preface -- Gene Therapy for Arthritis -- Why Gene Therapy in Arthritis? -- Ex Vivo Strategy -- In Vivo Strategy -- Vectors for Gene Transfer in Arthritis -- The Target Genes -- Different Promoter to Provide Safe and Targeted Gene Expression -- What Have We Learnt From Preclinical Studies? -- Clinical Experience of Gene Therapy in Ra -- Conclusion -- References -- Gene Therapy for the Treatment of Inflammatory Bowel Disease -- Inflammatory Bowel Disease -- Pathogenesis of Ibd -- Treatment of Ibd 8211; Current Clinical Standards -- Pharmacologic Therapy -- Surgical Therapy -- New Approaches to the Treatment of Ibd -- Blocking Pro-Inflammatory Cytokine Activity -- Anti-Inflammatory Cytokine Treatment -- T Cell Inhibition -- Promoting Intestinal Repair -- Modifying the Enteric Microbiota -- Applications of Nucleic Acid-Based Therapies in Ibd Treatment -- Concluding Remarks -- References -- Gene Therapy for Diabetes -- Introduction -- Approaches for Treating Type 1 Diabetes By Gene Transfer -- Prevention of Autoimmunity By Gene Therapy -- Islet Transplantation With Immunoregulatory Gene Transfection -- Induction of Insulin-Producing…
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