Glutamate and Addiction

by Herman, Barbara H.

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Title Statements

Full title :Glutamate and Addiction / edited by Barbara H. Herman, Jerry Frankenheim, Raye Z. Litten, Philip H. Sheridan, Forrest F. Weight, Steven R. Zukin.

Summary

The past decade has witnessed a growing body of preclinical and clinical evidence that glutamatergic systems may play a pivotal role in drug dependence. In Glutamate and Addiction, world-renowned scientific experts critically review all of this evidence and make the case for the role of glutamatergic systems in both the etiology and treatment of addiction disorders. The authors examine the glutamate connection in stimulant drugs of abuse (cocaine, amphetamine, and methamphetamine), in opiate addiction, and in alcohol abuse and dependence. Using a variety of pharmacological, biochemical, genetic, and brain imaging techniques, these investigators show precisely how glutamate is involved in the etiology of addictions and how blocking or activating certain elements of the glutamatergic system appear to alleviate particular components of addiction. Their survey takes in both clinical approaches using medications that influence glutamate and cutting-edge preclinical approaches that manipulate specific subtypes of glutamate receptors or specific substrates of the "glutamate cascade" to determine their roles in various addictive states. The discussion includes a full review of possible treatments of addiction using glutamatergic antagonists and co-agonists such as acamprosate to modify specific aspects of glutamate function in the central nervous system. Illuminating, authoritative, and forward looking, Glutamate and Addiction clarifies for the first time the relationship between glutamatergic systems and addiction and sets the stage for productive experimental and clinical investigations of many of today's emerging therapeutics for addictive disorders.

Edition Statements

Publication Date:2002.

Publication Statements

Publisher(s):Humana Press, Imprint
Place of Publication:Totowa, NJ
Language:eng
Publication Date:2002.

The Physical Object

Description:1 online resource (XVIII, 440 pages) : : online resource

Edition Identifiers

ISBN:9781592593064, 1592593062, 9781617372346, 161737234X
DOI:10.1007/978-1-59259-306-4
oclc:on1058344052
LC Classification:RM1-950
Dewey Decimal:615

I. Introduction: Physiology and Pharmacology of Glutamate -- 1 Molecular Pharmacology and Physiology of Glutamate Receptors -- 2 Pharmacology of Glutamate Receptors -- 3 Glutamate and Neurotoxicity -- 4 Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity -- 5 Role of the NMDA Receptor in Neuronal Apoptosis and HIV-Associated Dementia -- II. Glutamate: Stimulant Drugs of Abuse (Cocaine, Amphetamine, Methamphetamine) -- 6 Role of Glutamate and Nitric Oxide in the Acquisition and Expression of Cocaine-Induced Conditioned Increases in Locomotor Activity -- 7 Interactions of Dopamine, Glutamate, and GABA Systems in Mediating Amphetamine- and Cocaine-Induced Stereotypy and Behavioral Sensitization -- 8 Addiction and Glutamate-Dependent Plasticity -- 9 Glutamate and Dopamine Interactions in the Motive Circuit: Implications for Craving -- 10 Glutamate Cascade from Metabotropic Glutamate Receptors to Gene Expression in Striatal Neurons: Implications for Psychostimulant Dependence and Medication -- 11 Glutamate Neurotransmission in the Course of Cocaine Addiction -- 12 Glutamate and the Self-Administration of Psychomotor-Stimulant Drugs -- 13 Roles of Glutamate,…

Subjects

Acide glutamique -- Effets physiologiqu… Glutamic acid ; Physiological effect Médecine Medicine medicines (material) Neurosciences Pharmacologie pharmacology Polytoxicomanie -- Physiopathologie Substance abuse -- Pathophysiology