Human stem cell toxicology

by Sherley, James L.

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Title Statements

Full title :Human stem cell toxicology / edited by James L. Sherley,....

Summary

Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical, and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms, are covered by expert authors.

Edition Statements

Publication Date:copyright 2016

Publication Statements

Publisher(s):Royal Society of Chemistry
Place of Publication:Cambridge, UK
Language:eng
Publication Date:copyright 2016

The Physical Object

Description:1 vol. (XV-299 p.) : : ill. en noir et en coul., couv. ill. en coul. ; : 25 cm.

Edition Identifiers

ISBN:9781782624219 (rel), 178262421X (rel)
oclc:on1296259422
LC Classification:QH588.S83
Dewey Decimal:616.027 74

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