Intracellular calcium-dependent proteolysis

Intracellular Calcium-Dependent Proteolysis explains what is now known about calpains, which are intracellular, non-lysosomal enzymes involved in intracellular protein catabolism. The book provides a comprehensive overview of topics ranging from the molecular biology of the calpains and their specific inhibitor protein (calpastatin) to physiologic and pathologic consequences of the presence of this proteolytic system in many model cells and tissues. Several theoretical functions of the calpains are discussed, including their potential roles in muscle protein turnover, platelet activation, membrane fusion, and synaptic plasticity. Intracellular Calcium-Dependent Proteolysis is a valuable source of information for researchers and students interested in the regulation of intracellular protein catabolism and the general effects of Ca2+ on cell function.

Cover; Title Page; Copyright Page; TABLE OF CONTENTS; I. STRUCTURAL AND REGULATORY PROPERTIES OF THE CALPAINS AND CALPASTATINS; Chapter 1 Historical Background and Current Status of the Ca2+-Dependent Proteinase System; Chapter 2 The Structures of Calpains and the Calpain Gene; Chapter 3 Structure-Function Relationships of Calpastatins; Chapter 4 Calpain Substrate Specificity; Chapter 5 Protein and Peptide Inhibitors of Calpains; Chapter 6 Subunit Autolysis and Regulation of Calpain II Activity; Chapter 7 Regulation of Calcium-Dependent Protease Activity in Vitro

Chapter 8 The Regulation of Calpains by Interaction with CalpastatinsChapter 9 Calcium-Dependent Proteinases and Their Inhibitor in Drosophila; Chapter 10 Calcium-Dependent Proteinases in Crustaceans; II. FUNCTION OF THE CALCIUM-DEPENDENT PROTEOLYTIC SYSTEM IN NORMAL PHYSIOLOGY AND PATHOPHYSIOLOGY; Chapter 11 Introduction: Physiological Significance of the Calcium-Calpastatin System; Chapter 12 The Calpain-Calpastatin System and Membrane Fusion; Chapter 13 Calpains and Regulation of Protein Kinase C; Chapter 14 Calpains and the Cytoskeleton; Chapter 15 Calpains and Hemostasis

Chapter 16 Erythrocyte Calpain in Health and…