Klotho

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Klotho is the latest edition of a series first published in 1943 on Vitamins and Hormones and the longest-running serial published by Academic Press. It provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic, with volumes focusing on a single molecule or on a disease that is related to vitamins or hormones that are interpreted broadly so that related substances, such as transmitters, cytokines, growth factors, and others can be reviewe…

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Title Statements

Full title :Klotho / series editor, Gerald Litwack.

Summary

Edition Statements

Publication Date:2016.
Edition:First edition

Publication Statements

Publisher(s):Academic Press is an imprint of Elsevier
Place of Publication:Cambridge, MA
Language:eng
Publication Date:2016.

The Physical Object

Description:1 online resource (xiv, 338 pages) : : color illustrations.

Edition Identifiers

ISBN:012805235X, 9780128052358
oclc:ocn948985646
LC Classification:QP552.M44
Dewey Decimal:572/.696

1. Introduction2. The Components of the Signaling Complex; 2.1. Klotho-Beta; 2.1.1. The Klotho Family of Receptors; 2.1.2. KLB Structure; 2.1.3. KLB Tissue Expression; 2.2. Fibroblast Growth Factor Receptors; 2.2.1. The Fibroblast Growth Factor Receptor Family; 2.2.2. Fibroblast Growth Factor Receptor Structure; 2.2.3. FGFR1c Tissue Expression; 2.3. Endocrine FGF21; 2.3.1. The Fibroblast Growth Factor Family; 2.3.2. FGF Structure; 2.3.3. Endocrine FGF21 Structure; 2.3.4. Endocrine FGF21 Tissue Expression; 3. Specific Interactions Driving Complex Formation; 3.1. Interaction of FGF21 and KLB.

3.2. Interaction of FGF21 and FGFR13.3. Interaction of KLB and FGFR1; 3.4. KLB Domains Relevant for Binding; 4. Stoichiometry of the Signaling Complex; 4.1. Preformed KLB Heterodimers with FGFR1c/4; 5. Other Regulators of the Signaling Complex Formation; 5.1. KLB Inactivation by the Galectin Lattice; 5.2. ECM Regulation of FGFRs; 5.3. Fibroblast Growth Factor Receptor 5; 6. Summary; References; Chapter Three: Klotho-Dependent Cellular Transport Regulation; 1. Introduction; 1.1. Gene Structure and Klotho Protein Types; 1.2. Ectodomain Shedding and Some Functions Mediated by Klotho.

1.3. Transp…