Mendelian randomization: methods for using genetic variants in causal estimation

by Burgess, Stephen

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Title Statements

Full title :Mendelian randomization : methods for using genetic variants in causal estimation / Stephen Burgess, Department of Public Health and Primary Care, University of Cambridge, UK, Simon G. Thompson, Department of Public Health and Primary Care, University of Cambridge.

Edition Statements

Publication Date:2015

Publication Statements

Publisher(s):CRC Press, Taylor & Francis Group
Place of Publication:Boca Raton
Language:eng
Publication Date:2015

Notes

"A Chapman & Hall book."

The Physical Object

Description:xiv, 210 pages : : illustrations ; : 24 cm.

Edition Identifiers

ISBN:9781466573178, 1466573171
oclc:ocn928022079
LC Classification:RB155
Dewey Decimal:616.042015195

Using Genetic Variants as Instrumental Variables to Assess Causal Relationships. Introduction and motivation -- What is Mendelian randomization? -- Assumptions for causal inference -- Methods for instrumental variable analysis -- Examples of Mendelian randomization analysis -- Generalizability of estimates from Mendelian randomization -- Statistical Issues in Instrumental Variable Analysis and Mendelian Randomization. Weak instruments and finite-sample bias -- Multiple instruments and power -- Multiple studies and evidence synthesis -- Example: The CRP CHD Genetics Collaboration -- Prospects for Mendelian Randomization. Future directions -- Bibliography - Index.

Subjects

genetic variation Génétique médicale -- Méthodes statisti… Human genetics -- Variation Medical genetics -- Statistical methods Mendelian Randomization Analysis -- met… Statistics as Topic -- methods Variabilité génétique