Molecular immunotoxicology

The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.

Formerly CIP.

The Evolution of Immunotoxicology / Michael I. Luster -- Overview on the Mechanisms Underlying Chemical-Induced Immunotoxicity / Emanuela Corsini -- Use of Toxicogenomics in Immunotoxicology / Rachel Frawley, Dori Germolec, Henk van Loveren -- Breakdown of the Molecular Processes Driving the Adverse Outcome Pathways (AOPs) of Skin and Respiratory Sensitization Induction in Humans Exposed to Xenobiotics and Proteins / Erwin L. Roggen -- Chemical Allergen-Induced Skin Cell Activation / Stefan F. Martin, Philipp R. Esser -- The Aryl Hydrocarbon Receptor (AhR) as a Mediator of Adverse Immune Reactions / Charlotte Esser -- Immunotoxicological Effects of Pharmaceuticals on Signal Transduction in Innate and Adaptive Immunity / Tsuguto Toda, Kazuichi Nakamura -- Promises and Challenges with Immunomodulatory Biologics / Rafael A. Ponce -- The Nonclinical Evaluation of Biotechnology-Derived Pharmaceuticals, Moving on after the TeGenero Case / Jan Willem van der Laan, Carla Herberts, David Jones, Susan J Thorpe, Richard Stebbings, Robin Thorpe -- Glucocorticoid-Induced Immunomodulation / Simona Ronchetti, Graziella Migliorati, Carlo Riccardi -- Particulate Matter-Induced Immune Activation / …