Nitric oxide: biology and pathobiology

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Edited by Nobel Laureate Louis J. Ignarro Up-to-date therapeutic implications of nitric oxide research Authored by world experts on nitric oxide Detailed research of the biochemistry and synthesis of nitric oxide.

Section I. Chemical Biology -- Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes -- Nitric oxide redox biochemistry in lipid environments -- Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration -- Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes -- Section II. Principles of Biology -- A. Nitric Oxide Synthases -- Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal -- Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases -- Regulation of the expression of inducible nitric oxide synthase -- Molecular Regulation of Inducible Nitric Oxide Synthase -- B. Guanylate Cyclase and Cyclic GMP -- Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation -- C. Nitric Oxide Signaling -- Untargeted Discovery of NO-modified Proteins.

Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids -- Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 -- The Regulation of Cell Energetics and Mitochondrial Signaling by …