Nitric oxide: biology and pathobiology

Nitric oxide (NO) is a gas naturally found in the body that conveys information between cells. In the last decade researchers have found that NO is a signaling molecule of key importance for the cardiovascular system, regulating blood pressure and blood flow to different organs. In addition, discoveries surrounding nitric oxide's role as a principal neurotransmitter moderating erectile function, a pathophysiological negotiator and messenger in inflammation, and a weapon against infections have increased research attention across the fields of biochemistry, chemistry, molecular biology, gene.

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GENETIC DISEASES MEDIATED BY BH[sub(4)] DEFICIENCY

Front Cover; Nitric Oxide: Biology and Pathobiology; Copyright Page; Contents; Section I. Chemical Biology; Chapter 1 Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes; ABSTRACT; INTRODUCTION; CONTEXT DEPENDENCE OF NO RESPONSE; CELLULAR MILIEU AND NO REDOX CHEMISTRY; CONCENTRATION RANGE OF ENDOGENOUSLY GENERATED NO; KINETIC DETERMINANTS FOR MOLECULAR TARGET INTERACTIONS; CONCLUSION; REFERENCES; Chapter 2 Nitric Oxide Redox Biochemistry in Lipid Environments; SUMMARY; CHEMISTRY OF NITRIC OXIDE AND REACTIVE NITROGEN SPECIES

PHYSICAL INTERACTIONS OF NITRIC OXIDE AND REACTIVE NITROGEN SPECIES WITH LIPID MEMBRANES AND LIPOPROTEINSREACTIONS OF REACTIVE NITROGEN SPECIES IN LIPID MILIEU; LIPID NITRATION AND ITS ROLE IN INFLAMMATION; CONCLUDING REMARKS; ACKNOWLEDGMENTS; REFERENCES; Chapter 3 Mechanisms and Biological Consequences of Peroxynitrite-Dependent Protein Oxidation and Nitration; SUMMARY; OVERVIEW OF PEROXYNITRITE BIOCHEMISTRY; PEROXYNITRITE-MEDIATED AMINO ACID AND PROTEIN MODIFICATIONS; BIOLOGICAL CONSEQUENCES OF PEROXYNITRITE-MEDIATED PROTEIN OXIDATION AND NITRATION; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES

Chapter 4 Systems Approaches to Unraveling Ni…