NMR spectroscopy in drug development and analysis
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (& 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility …
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- Full title :NMR spectroscopy in drug development and analysis / U. Holzgrabe, I. Wawer, B. Diehl.
Summary
Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (& 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition o.
Read More ↓Edition Statements
- Publication Date:©1999.
Publication Statements
- Publisher(s):Wiley-VCH
- Place of Publication:Weinheim
- Language:eng
- Publication Date:©1999.
The Physical Object
- Description:1 online resource (299 pages) : : illustrations
Edition Identifiers
- ISBN:9783527613656, 352761365X, 9783527613649, 3527613641
- DOI:10.1002/9783527613649
- oclc:ocn649863884
- LC Classification:RM301.25
- Dewey Decimal:615.19
Table of Contents
NMR spectroscopy in the European regulatory dossier / S. Branch -- Analysis of drugs / B.W.K. Diehl and U. Holzgrabe -- pH-dependent NMR measurements / G. Hägele and U. Holzgrabe -- Complexation behaviour of drugs studied by NMR / B.W.K. Diehl and U. Holzgrabe -- Determination of the isometric composition of drugs / B.W.K. Diehl and U. Holzgrabe -- On-line coupling of HPLC or SFC / K. Albert -- NMR of body fluids / U. Holzgrabe -- NMR as a tool in drug research / G. Gemmecker -- Ligand-cyclodextrin complexes / B. Chankvetadze, G. Blaschke and G. Pintore -- Ligand-membrane interaction / J.K. Seydel -- Solid-state NMR in drug analysis / I. Wawer -- MR imaging and MR spectroscopy / I. Wawer.
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