Pharmaceutical Perspectives of Nucleic Acid-Based Therapy
Gene Expression. Modulation of Gene Expression. Biophysical Aspects of Nucleic Acids and Carriers. Intracellular Trafficking. Nucleic Acid Delivery Systems. Biodistribution and Pharmacokinetics. Clinical Applications of Gene Therapy.
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- Full title :Pharmaceutical Perspectives of Nucleic Acid-Based Therapy.
Summary
Gene Expression. Modulation of Gene Expression. Biophysical Aspects of Nucleic Acids and Carriers. Intracellular Trafficking. Nucleic Acid Delivery Systems. Biodistribution and Pharmacokinetics. Clinical Applications of Gene Therapy.
Read More ↓Edition Statements
- Publication Date:©2005.
- Edition:1st ed
Publication Statements
- Publisher(s):CRC Press
- Place of Publication:Boca Raton
- Language:eng
- Publication Date:©2005.
Notes
15 Cationic lipid-based gene delivery.
The Physical Object
- Description:1 online resource (521 pages)
Edition Identifiers
- ISBN:9780203300961, 0203300963
- oclc:on1058469978
- LC Classification:RM666.N87 ǂb P476 2002eb
- Dewey Decimal:616/.042
Table of Contents
Book Cover -- Half-Title -- Title -- Copyright -- Dedication -- Contents -- Color plates -- Figures -- Tables -- Contributors -- Foreword -- Preface -- 1 Basic components of gene expression plasmids -- INTRODUCTION -- ESSENTIAL ELEMENTS OF EXPRESSION PLASMID VECTORS -- TRANSCRIPTIONAL REGULATORY ELEMENTS -- CHROMOSOMAL ELEMENTS -- RNA PROCESSING -- TRANSCRIPTIONAL TERMINATION SEQUENCES -- STABILITY OF TRANSCRIPTS -- TRANSLATION CONTROL -- MULTIPLE GENE PRODUCTS FROM A SINGLE mRNA -- MULTIPLE CLONING SITE OR POLYLINKER -- PERSISTENCE OF GENE EXPRESSION -- CONCLUDING REMARKS -- REFERENCES -- 2 Inducible gene expression strategies in gene therapy -- INTRODUCTION -- GENERAL APPROACHES -- INDUCIBLE GENE EXPRESSION SYSTEMS -- STRESS INDUCIBLE PROMOTERS -- HEAT SHOCK PROMOTERS -- IONIZING RADIATION INDUCIBLE PROMOTERS -- HYPOXIA INDUCIBLE PROMOTERS -- REGULATED EXPRESSION PROMOTERS -- Metabolic genes -- Metallothionein -- Tetracycline/Doxycycline 'gene switches' -- COMBINATION STRATEGIES -- LEAKY VERSUS TIGHTLY CONTROLLED EXPRESSION -- CONCLUDING REMARKS -- ACKNOWLEDGMENT -- REFERENCES -- 3 Modulation of gene expression by antisense oligonucleotides -- INTRODUCTION -- MECHANISMS OF ACTIO…
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