Platelets

PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists Integrates the entire field of platelet biology, pathophysiology, and clinical medicine Full color reference comprising 64 chapters, 1400 pages, and 16,000 references Contributions from 126 world leaders in their fields New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets ex vivo.

Front Cover; Platelets; Copyright Page; Contents; List of Contributors; Preface; Foreword: A Brief History of Ideas About Platelets in Health and Disease; I. The Role of Platelets in Human Hemostasis, Platelet Transfusion, and the Bleeding Time; II. Immune Thrombocytopenia; III. Alloantigens, Single Nucleotide Polymorphisms, and Alloimmune Thrombocytopenias; IV. Platelet Physiology, Assays of Platelet "Adhesiveness", ADP, Platelet Aggregation, Myocardial Infarction, and P2Y12 Anta ...

V. Aspirin, Arachidonic Acid, Prostaglandins, Gpiib-iiia, Nitric Oxide, Endothelial Gpiib-iiia, and AngiogenesisVI. Clot Retraction, Glanzmann Thrombasthenia, GPIIb-IIIa Receptor, and GPIIb-IIIa Antagonists; VII. Bernard-Soulier Syndrome, the Gpib-IX-V Complex, von Willebrand Factor, Shear, ADAMTS-13, and Thrombotic Thrombocytopen ... ; VIII. Thrombin-induced Platelet Activation; IX. Platelets and Metastases; X. Reflections on the Past and Thoughts About the Future; Reference List; I. Platelet Biology; 1 The Evolution of Mammalian Platelets; I Introduction; II Invertebrates

III Nonmammalian VertebratesIV Comparative Hemostasis; V A Comparison of Human Platelets and Limulus Amebocytes; VI The Evolut…