Prodrugs: Challenges and Rewards Part 1
by Borchardt, Ronald T. Hageman, Michael J. Maag, Hans Oliyai, Reza Stella, Valentino J. Tilley, Jefferson W.
Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to devel…
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- Full title :Prodrugs : Challenges and Rewards Part 1 / edited by Valentino J. Stella, Ronald T. Borchardt, Michael J. Hageman, Reza Oliyai, Hans Maag, Jefferson W. Tilley.
Summary
Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs continue to be a fertile area of research. There are a number of small pharmaceutical/biotech companies dedicated to using prodrugs for the delivery of older but problematic drugs as well as to developing broad-based prodrug technologies for application to new and future drugs. These volumes represent a comprehensive guide to prodrugs and will guide the reader through the current status of the prodrug concept and its many applications and to highlight its many successes in overcoming formulation and delivery of problematic drugs.
Read More ↓Edition Statements
- Publication Date:2007.
Publication Statements
- Publisher(s):Springer New York
- Place of Publication:New York, NY
- Language:eng
- Publication Date:2007.
The Physical Object
- Description:1 online resource (XVIII, 1464 pages) : : online resource
Edition Identifiers
- ISBN:1281493880, 9781281493880, 9786611493882, 6611493883
- DOI:10.1007/978-0-387-49785-3
- oclc:on1066635359
- LC Classification:RM1-950
- Dewey Decimal:615
Table of Contents
A Case for Prodrugs -- A Case for Prodrugs -- Problems Addressable by Prodrugs -- Prodrug Approaches to Enhancing the Oral Delivery of Poorly Permeable Drugs -- Topical Delivery Using Prodrugs -- Prodrug approaches to ophthalmic drug delivery -- Overcoming Poor Aqueous Solubility of Drugs for Oral Delivery -- Prodrugs and Parenteral Drug Delivery -- Poly (ethylene glycol) Prodrugs: Altered Pharmacokinetics and Pharmacodynamics -- Prodrugs to Reduce Presystemic Metabolism -- Controlled Release -- Small Molecules -- Controlled Release -- Macromolecular Prodrugs -- Controlled Release -- Proenzymes -- Targeting -- Theoretical and Computational Models -- Targeting -- Cancer -- Small Molecules -- Monoclonal Antibody Drug Conjugates for Cancer Therapy -- Antibody-Directed Enzyme Prodrug Therapy -- Prodrugs for Liver-targeted Drug Delivery -- Prodrug Approaches for Drug Delivery to the Brain -- Lymphatic Absorption of Orally Administered Prodrugs -- Colonic Delivery -- Functional Group Approach to Prodrugs -- Prodrugs of Carboxylic Acids -- Prodrugs of Alcohols and Phenols -- Prodrugs of Amines -- Prodrugs of Amides, Imides and Other NH-acidic Compounds -- Prodrugs of Benzamidines -- Prod…
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